“Zero to Birth: How the Human Brain Is Built” with Professor William Harris

Zero to Birth reviewed on Bridging the Gaps

A single fertilised egg generates an embryo. Different cell types in this embryo develop into various organs of a new human being, including a new human brain. Everything starts with a single fertilised egg, and in the embryo, some embryonic cells develop into neural stem cells that construct the brain. By the time a baby is born, its brain is already made up of billions of precisely designed neurons that are connected by trillions of synapses to form a small, compact but incredibly powerful supercomputer. In his recent book “Zero to Birth: How the Human Brain Is Built” pioneering experimental neurobiologist professor William Harris takes the reader on an incredible journey to the very edge of creation, from the moment an egg is fertilised to every stage of a human brain’s development in the womb — and even a bit beyond. In this episode of Bridging the Gaps, I speak with Professor William Harris the process of how the brain is built.

William Harris is professor emeritus of anatomy at the University of Cambridge. He is the coauthor of Development of the Nervous System and Genetic Neurobiology and the co-editor of Retinal Development. He is a fellow of the Royal Society.

We begin by examining the evolutionary history of the brain, which spans billions of years and in the Proterozoic eon, when multicellular animals first descended from single-celled organisms, and then we discuss how the development of a fetal brain over the course of nine months reflects the brain’s evolution through the ages. We discuss the emergence of first neural stem cells and how the formation of the neural plate and then its progress to the neural tube give the first glimpses of the development of the brain in an embryo. We discuss in detail how cells divide and create neural stem cells and then how these stem cells start producing neurons. A fascinating topic that we then cover is how individual neurons form connections with other neurons. Professor Harris explains how comparative animal studies have been crucial to understanding what makes a human brain human, and how advances in science are assisting us in understanding many qualities that don’t manifest until later in life. This has been a fascinating discussion on an intriguing topic.

Complement this discussion with The Spike: Journey of Electric Signals in Brain from Perception to Action with Professor Mark Humphries and then listen to The Self-Assembling Brain” and the Quest for Artificial General Intelligence with Professor Peter Robin Hiesinger

By |October 15th, 2022|Biology, Neuroscience, Podcasts, Research|
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“The Case Against Reality” and The Hard Problem of Consciousness with Professor Donald Hoffman

What is the true nature of reality? Does the objective reality reported back by our senses paint a complete picture of the true reality? Is it possible that the world we see is not objective reality and it is just an interface to a deeper, true reality. In his book “The Case Against Reality: Why Evolution Hid the Truth from Our Eyes” cognitive scientist Donald Hoffman Challenges leading scientific theories that claim that our senses report back objective reality. He argues that while we should take our perceptions seriously, we should not take them literally. He presents the evolutionary concept of “Fitness Beats Truth” to demonstrate that evolution very probably moulded our minds for fitness rather than accuracy, resulting in the mismatch between “things-in-themselves” and our perceptions of them. In this episode of Bridging the Gaps I speak with professor Donal Hoffman; we discuss his “Interface Theory of Perception” and dig deep on latest research in cognitive science and perception, and how it relates to our understanding of the true nature of reality.

Donald Hoffman is a professor of Cognitive Sciences at the University of California, Irvine. He is a cognitive psychologist and popular science author. His research focuses on perception, evolution, and consciousness.

We begin by discussing the present understanding of the hard problem of consciousness. Then we talk about Hoffman’s view that all main scientific theories, such as Einstein’s theory, theories and our present understanding of Quantum Physics and the theory of natural selection, all inform us that our present approach of trying to understand reality is not working. I then ask him that why in his view we have evolved in a manner that we don’t see the real underlying reality and we just perceive a superficial realty. We then discuss in detail his theory and ideas about the nature of reality. We touch upon the question that do we live in a simulation. We also discuss Panpsychism. Finally I ask that how the research on the question of the true nature of reality should proceed.

Complement this discussion with From Consciousness to Synthetic Consciousness: From One Unknown to Another Unknown with David Chalmers and then listen to Why You Are Not Your Brain? A Conversation on Consciousness with Alva Noe.

By |July 19th, 2022|Neuroscience, Physics, Podcasts|
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Augmented Thinking: The New Convergence of Art, Technology, and Science with Professor Julio Ottino

We live in an age of increasing complexity and uncertainty. We live in a time when humanity faces extremely complex challenges. Our ability, or lack thereof, to create solutions to such extremely complicated challenges may determine our long-term survival as a civilization. The question is: is our existing style of thinking adequate, or do we require a new style of thinking in order to innovate and lead into the future. In their recent book Julio Ottino and Bruce Mau make a case for “The Nexus”, a radically new way of thinking — one in which art, technology, and science converge to expand our creativity and augment our insight. In this episode or Bridging the Gaps I speak with Julio Ottino who explains “the Nexus” and guides us how to embrace the powerful idea of complementarity, where opposing extremes coexist. We discuss how blurring the lines between the three major realms of human creation — art, technology, and science — results in a significant expansion of thinking spaces and a richness of potential ideas.

Julio Ottino is Dean of Engineering and Applied Sciences, and a professor of Chemical and Biological Engineering at Northwestern University, in Illinois. He is also the founding co-director of Northwestern University’s Institute on Complex Systems. He is a thought leader, author, artist, and internationally recognized researcher in chaos theory and complex systems whose work has been featured in “Nature”, “Science”, and “Scientific American”.

We begin our discussion by looking back at the time before the divergence of disciplines and how key figures in science immensely benefited from talents and skills in a variety of fields. Then we talk about how, when, and why the disciplines diverged. We delve into the concept of “the Nexus” and discuss whole-brain thinking. The book is jam-packed with wonderful photographs and diagrams. I ask Professor Ottino to describe the process that he followed to write this book. This has been a wonderful discussion.

Complement this discussion with Asking Better Questions for Creative Problem Solving, Innovation and Effective Leadership with Hal Gregersen and with “Learning How to Learn”: Techniques to Help You Learn with Dr Barbra Oakley and then listen to Multiple Intelligences, Future Minds and Educating The App Generation: A discussion with Dr Howard Gardner

By |June 27th, 2022|Knowledge, Podcasts, Research, Technology|
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