“Zero to Birth: How the Human Brain Is Built” with Professor William Harris

Zero to Birth reviewed on Bridging the Gaps

A single fertilised egg generates an embryo. Different cell types in this embryo develop into various organs of a new human being, including a new human brain. Everything starts with a single fertilised egg, and in the embryo, some embryonic cells develop into neural stem cells that construct the brain. By the time a baby is born, its brain is already made up of billions of precisely designed neurons that are connected by trillions of synapses to form a small, compact but incredibly powerful supercomputer. In his recent book “Zero to Birth: How the Human Brain Is Built” pioneering experimental neurobiologist professor William Harris takes the reader on an incredible journey to the very edge of creation, from the moment an egg is fertilised to every stage of a human brain’s development in the womb — and even a bit beyond. In this episode of Bridging the Gaps, I speak with Professor William Harris the process of how the brain is built.

William Harris is professor emeritus of anatomy at the University of Cambridge. He is the coauthor of Development of the Nervous System and Genetic Neurobiology and the co-editor of Retinal Development. He is a fellow of the Royal Society.

We begin by examining the evolutionary history of the brain, which spans billions of years and in the Proterozoic eon, when multicellular animals first descended from single-celled organisms, and then we discuss how the development of a fetal brain over the course of nine months reflects the brain’s evolution through the ages. We discuss the emergence of first neural stem cells and how the formation of the neural plate and then its progress to the neural tube give the first glimpses of the development of the brain in an embryo. We discuss in detail how cells divide and create neural stem cells and then how these stem cells start producing neurons. A fascinating topic that we then cover is how individual neurons form connections with other neurons. Professor Harris explains how comparative animal studies have been crucial to understanding what makes a human brain human, and how advances in science are assisting us in understanding many qualities that don’t manifest until later in life. This has been a fascinating discussion on an intriguing topic.

Complement this discussion with The Spike: Journey of Electric Signals in Brain from Perception to Action with Professor Mark Humphries and then listen to The Self-Assembling Brain” and the Quest for Artificial General Intelligence with Professor Peter Robin Hiesinger

By |October 15th, 2022|Biology, Neuroscience, Podcasts, Research|
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Augmented Thinking: The New Convergence of Art, Technology, and Science with Professor Julio Ottino

We live in an age of increasing complexity and uncertainty. We live in a time when humanity faces extremely complex challenges. Our ability, or lack thereof, to create solutions to such extremely complicated challenges may determine our long-term survival as a civilization. The question is: is our existing style of thinking adequate, or do we require a new style of thinking in order to innovate and lead into the future. In their recent book Julio Ottino and Bruce Mau make a case for “The Nexus”, a radically new way of thinking — one in which art, technology, and science converge to expand our creativity and augment our insight. In this episode or Bridging the Gaps I speak with Julio Ottino who explains “the Nexus” and guides us how to embrace the powerful idea of complementarity, where opposing extremes coexist. We discuss how blurring the lines between the three major realms of human creation — art, technology, and science — results in a significant expansion of thinking spaces and a richness of potential ideas.

Julio Ottino is Dean of Engineering and Applied Sciences, and a professor of Chemical and Biological Engineering at Northwestern University, in Illinois. He is also the founding co-director of Northwestern University’s Institute on Complex Systems. He is a thought leader, author, artist, and internationally recognized researcher in chaos theory and complex systems whose work has been featured in “Nature”, “Science”, and “Scientific American”.

We begin our discussion by looking back at the time before the divergence of disciplines and how key figures in science immensely benefited from talents and skills in a variety of fields. Then we talk about how, when, and why the disciplines diverged. We delve into the concept of “the Nexus” and discuss whole-brain thinking. The book is jam-packed with wonderful photographs and diagrams. I ask Professor Ottino to describe the process that he followed to write this book. This has been a wonderful discussion.

Complement this discussion with Asking Better Questions for Creative Problem Solving, Innovation and Effective Leadership with Hal Gregersen and with “Learning How to Learn”: Techniques to Help You Learn with Dr Barbra Oakley and then listen to Multiple Intelligences, Future Minds and Educating The App Generation: A discussion with Dr Howard Gardner

By |June 27th, 2022|Knowledge, Podcasts, Research, Technology|
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“Machines like Us: TOWARD AI WITH COMMON SENSE” with Professor Ronald Brachman

Machines Like us reviewed on Bridging the Gaps

There is a consensus among the researchers in the field of artificial intelligence and machine learning that today’s artificial intelligence systems are narrowly focused, are designed to tackle specialised tasks and cannot operate in general settings. An important feature of the human brain that enables us to operate in general settings, and in unfamiliar situations is our common sense. In their new book “Machines like Us:
TOWARD AI WITH COMMON SENSE” Hector Levesque and Ronald Brachman explain “why current AI systems hopelessly lack common sense, why they desperately need it, and how they can get it”. In this episode of Bridging the Gaps, I speak with Professor Ronald Brachman, one of the authors of this book. We discuss various topics covered in the book and explore the question, how we can create artificial intelligence with broad, robust common sense rather than narrow, specialised expertise.

Professor Ron Brachman is the director of the Jacobs Technion-Cornell Institute and is a professor of computer science at Cornell University. Previously, he was the Chief Scientist of Yahoo! and head of Yahoo! Labs. Prior to that, he was the Associate Head of Yahoo! Labs and Head of Worldwide Labs and Research Operations.

We start off with a detailed discussion about the progress that we have made in recent decades, in developing narrowly focused and task oriented artificial intelligence systems. Some of these systems outperform humans; however we do acknowledge and discuss the need for developing artificial intelligence systems that can operate in general settings. We discuss the concept of artificial general intelligence and explore how understanding “human common sense” and equipping AI with common sense is an extremely important milestone in our journey toward developing artificial general intelligence. We discuss the challenge of developing a clear and thorough understanding of the nature and working of human common sense. We explore how “common sense” might be modelled and incorporated in future artificial intelligence systems. We then discuss the future of artificial general intelligence.

Complement this discussion with Artificial Intelligence: A Guide for Thinking Humans” with Professor Melanie Mitchell and with Artificial Intelligence: Fascinating Opportunities and Emerging Challenges with Professor Bart Selman and then listen to 2062: The World That AI Made” with Professor Toby Walsh

By |June 4th, 2022|Artificial Intelligence, Computer Science, Future, Podcasts, Research, Technology|
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