“The Next 500 Years: Engineering Life to Reach New Worlds” with Professor Christopher Mason

We are the only known species that understands species go extinct. We also understand that climate calamity, apocalyptic war, or the demise of the sun in a few billion years will all inevitably bring life on Earth to an end. So it is extremely important we do whatever we can to avoid extinction. We have a moral obligation to prevent extinction, and we have a responsibility to act as life-form shepherds—not just for our species, but for all species on which we rely, as well as those yet to come. This may involve finding a new home planet, developing innovative ways to undertake long haul space journeys. This may also involve re-engineering life and human genetics for travelling to, and for surviving on other worlds. Dr Christopher Mason argues in his provocative and engaging book “The Next 500 Years: Engineering Life to Reach New Worlds” that we have a moral duty to do just that. In this episode of Bridging the Gaps I speak with Dr Christopher Mason and we discuss his inspiring vision of the next 500 years of spaceflight and human exploration.

Dr Christopher Mason is a professor of genomics, physiology, and biophysics at Weill Cornell Medicine and the Director of the WorldQuant Initiative for Quantitative Prediction. He is a geneticist and computational biologist who has been a Principal Investigator and Co-investigator of 11 NASA missions and projects.

We start by discussing the moral obligation, moral duty that we must protect our species against extinction and to ensure that life continues. We discuss the impact of living in hard and unfamiliar environment of space on the human body and talk through the findings of “the Twin Study” which examines the impact of nearly a full year in space on astronaut Scott Kelly, using his identical brother Mark as control. We then discuss moral and ethical dimensions of engineering life and making changes in human genome and undertaking genetic modifications of humans. We review the 500 years plan that Dr Chris Mason presents in this book and go through various phases of this plan. We talk about engineering of genomes, cellular engineering, synthetic biology and preparing humans for long haul space flights. We discuss in detail how CRISPR tool works and what it enables us to do. We also discuss feature and functional re-engineering of the human genome by borrowing features and functions from other species. We once again touch upon moral, ethical, and social implications of re-engineering life and try to imagine a future full of variety of life forms evolved through directed and iterative re-engineering of life, coming from the same source that is human.

Complement this discussion with The End of Astronauts”, Robotic Space Exploration and Our Future on Earth and Beyond with Professor Martin Rees and then listen to “Nano Comes to Life”: DNA NanoTech, Medicine and the Future of Biology with Professor Sonia Contera

By |May 19th, 2022|Biology, Future, Physics, Podcasts, Research|
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“The Joy of Science” with Professor Jim Al-Khalili

Can living scientifically empower us to navigate the complexities of today’s complex and unpredictable world? Can the joy of critical thinking and the effectiveness of the scientific method assist us in making better decisions? Can living a more rational life help us navigate modern life more confidently? In his new book “The Joy of Science” acclaimed physicist Jim Al-Khalili invites readers to engage with the world as scientists have been trained to do. He shows how the fundamental principles at the heart of scientific thinking, as well as the scientific process, are profoundly relevant to the perplexing times we live in and the tough choices we make. In this episode of Bridging the Gaps, I speak with professor Jim Al-Khalili and we thoroughly discuss very interesting and deeply intriguing ideas that he presents in this book.

Professor Jim Al-Khalili is a theoretical physicist at the University of Surrey where he holds a Distinguished Chair in physics as well as a university chair in the public engagement in science. He is a prominent author, broadcaster and one of Britain’s best-known science communicators.

I start our discussion with the question that how the discipline of science should be perceived. We acknowledge that there are many ways scientific work is carried out in many different disciplines. We discuss the issue of “relative truth” and how biases held by individuals impact their opinions and distort their view and lead them to their own version of truth. We explore how science deals with the issue of relative truth. We probe how the scientific method enables us to continue researching in the presence of uncertainty. We investigate the impact of misinformation and disinformation on the disciple and cause of science. We also touch upon how rational humans can become; can we think rationally only up to certain point. We discuss in detail how scientific information should be presented to policy makers that should enable and empower them to make better decisions and to make the right choices. Finally, I ask Professor Jim Al-Khalili to tell us about his research in the field of open quantum systems. This has been a fantastic discussion.

Complement this with Asking Better Questions for Creative Problem Solving, Innovation and Effective Leadership with Hal Gregersen and then listen to On Public Communication of Science and Technology with Professor Bruce Lewenstein

By |May 13th, 2022|Biology, Future, Information, Knowledge, Physics, Podcasts, Research, Technology|
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“Spark: The Life of Electricity and the Electricity of Life” with Professor Timothy Jorgensen

Spark Book Review at Bridging the Gaps

When we think about electricity, we most often think of the energy that powers various devices and appliances around us, or perhaps we visualise the lightning-streaked clouds of a stormy sky. But there is more to electricity and “life at its essence is nothing if not electrical”. In this episode of Bridging the Gaps, I speak with Professor Timothy Jorgensen and we discuss his recent book “Spark: The Life of Electricity and the Electricity of Life ”. The book explains the science of electricity through the lenses of biology, medicine and history. It illustrates how our understanding of electricity and the neurological system evolved in parallel, using fascinating stories of scientists and personalities ranging from Benjamin Franklin to Elon Musk. It provides a fascinating look at electricity, how it works, and how it animates our lives from within and without.

We start by discussing the earliest known experiences that humans had with electricity using amber. Amber was most likely the first material with which humans attempted to harness electricity, mostly for medical purposes. Romans used non-static electricity from specific types of fish. Moving on to Benjamin Franklin, we discuss how he attempted to harner the power of electricity and we discuss the earliest forms of devices to store electric charge. We then discuss experiments conducted by Luigi Galvani on dead frogs and by his nephew on dead humans using electricity. As interest in electricity grew, many so-called treatemnts for ailments such as headaches, for bad thoughts and even for sexual difficulties also emerged that were based on the use of electricity; we discuss few interesting examples of such treatments. We then move on to reviewing the cutting edge use of electricity in medical science and discussed medial implants, artificial limbs and deep stimulation technologies and proposed machine-brain interfaces. This has been a fascinating discussion.

Complement this discussion by listening to he Spike: Journey of Electric Signals in Brain from Perception to Action with Professor Mark Humphries and then listen to On Public Communication of Science and Technology with Professor Bruce Lewenstein

By |March 17th, 2022|Artificial Intelligence, Biology, Future, Podcasts, Research|
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